Page 35 - World Journal of Laparoscopic Surgery

Role of Helicobacter pylori in Chronic Abdominal Pain and Endoscopy-suggested Gastritis
of Thapa et al. reported endoscopic gastritis in 76% of the patients Ethics Committee Approval
and the study of Uotani et al. and McNicholl et al. suggested 87 This study has been approved by institutional ethics committee.
and 85.9% positive cases of RUT, respectively. 8,13,14 The difference
in the results may be due to the difference in the geographic Clinical Significance
distribution of the studies, variability in the studied patients. Early diagnosis of H. pylori is essential to formulate early and
Moreover, the sensitivity and specificity of the commercial kits appropriate clinical strategies for better management of the patient.
used in the studies can also influence the results. 5,8,10 Here, RUT is a well-known diagnostic test that is rapid, cheap, and simple.
endoscopic findings were found to be significantly associated It detects urease in or on gastric mucosa produced by the bacteria.
with RUT (p = 0.013); this suggests that endoscopic findings are
a sensitive indicator of H. pylori infection. This is in accordance references
with the previous reports. 1,10 It is reported that the incidence
of H. pylori-induced gastritis increases with the increase in the 1. Adlekha S, Chadha T. A comparative study of endoscopic findings,
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age of the cases. A similar trend of infection was observed in rapid urease test and conventional histopathology in diagnosis of
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this study, which follows the findings of the previous report. Helicobacter pylori infection. Trop J Pathol Microbiol 2017;3(3):242–247.
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of India showed a higher incidence of H. pylori infection in 15–30 7-day and 14-day moxifloxacin-dexlansoprazole based triple therapy
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and 46–60 year age-group. The difference in the results may and probiotic supplement for Helicobacter pylori eradication in Thai
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and inability to afford health care. In this study, most of the 6. Malfertheiner P, Megraud F, O’Morain CA, et al. Management of
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H. pylori is Gram-negative bacteria commonly found in deep 2014;20(36):12847–12859. DOI: 10.3748/wjg.v20.i36.12847.
part of the mucous gel covering the gastric mucosa or between 8. Uotani T, Graham DY. Diagnosis of Helicobacter pylori using the
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RUT can provide a definitive diagnosis of H. pylori infection with the J 2019;6(12):4294–4298. DOI: 10.18203/2349-2902.isj20195215.
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World Journal of Laparoscopic Surgery, Volume 15 Issue 1 (January–April 2022) 33