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ORIGINAL ARTICLE
            The Outcome of Laparoscopic Ovarian Drilling in Patients

            with Clomiphene-resistant Polycystic Ovarian Syndrome in

            Ogbmoso, Nigeria: A Prospective Evaluation


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            Akintunde O Fehintola , Olufemi T Awotunde , Olumuyiwa A Ogunlaja , Samuel E Akinola , Sunday A Oladeji ,
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            Olurotimi I Aaron , Funmito O Fehintola 7
             AbstrAct
             Background: Polycystic ovary syndrome (PCOS) is commonly encountered in women with anovulatory infertility. The surgical ovarian drilling
             procedure aims to restore spontaneous ovulatory cycles. This function is similar to the goal of clomiphene citrate and/or metformin.
             Objective: We conducted this study to determine the outcome of laparoscopic ovarian drilling (LOD) among patients who presented with
             clomiphene-resistant PCOS.
             Materials and methods: The study was prospective in design. We studied 43 patients with clomiphene-resistant PCOS who had laparoscopic
             ovarian drilling (LOD) using monopolar diathermy at the Bowen University Teaching Hospital, Ogbomoso. The study took place between
             January 2014 and June 2016. Clinical data recorded at different intervals of follow-up included the menstrual pattern and reproductive history.
             Results: We successfully performed laparoscopic ovarian drilling without any complication. Four (9.3%) of the patients were lost to follow-up.
             Thirty (76.9%) of the remaining 39 patients resumed regular menstrual cycles with spontaneous ovulation, while 23 (59.1%) patients achieved
             spontaneous pregnancy within 6 and 18 months following LOD. No record of multiple pregnancies. Factors associated with failed LOD treatment
             included obesity and a long duration of infertility.
             Conclusion: LOD is a feasible and effective first-line treatment option in patients with clomiphene-resistant PCOS in sub-Saharan Africa. Emphasis
             should be on weight reduction with early application of LOD to treat patients with clomiphene-resistant PCOS. This will reduce the time to
             achieve pregnancy and the need for gonadotropins to induce ovulation.
             Keywords: Clomiphene-resistant polycystic ovary syndrome, Laparoscopic ovarian drilling, Treatment outcome.
             World Journal of Laparoscopic Surgery (2020): 10.5005/jp-journals-10033-1418

            IntroductIon
                                                               1 Department of Obstetrics and Gynaecology, Faculty of Clinical
            The most common endocrinopathy in women within the   Sciences, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria
            reproductive-age group is polycystic ovary syndrome (PCOS). It   2–5 Department of Obstetrics and Gynaecology, Bowen University
            affects about 6–8% of this age-group. 1–4  PCOS forms a spectrum of   Teaching Hospital, Ogbomoso, Oyo, Nigeria
            disorders from a heterogeneous collection of signs and symptoms.   6 Department  of  Anaesthesia,  Faculty  of  Clinical  Sciences,  Obafemi
            Its presentation may be mild in some, while reports show severe   Awolowo University, Ile-Ife, Osun, Nigeria
            disturbance of reproductive, endocrine, and metabolic functions in   7
                                                                Community Health Department, Faculty of Clinical Sciences, Obafemi
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            others.  The prevalence of PCOS varies among races and ethnicities   Awolowo University, Ile-Ife, Osun, Nigeria
            with a range between 5 and 10% 3
               Previous data reported the highest prevalence rate of 52%   Corresponding Author: Akintunde O Fehintola, Department of
                                                               Obstetrics and Gynaecology, Faculty of Clinical Sciences, Obafemi
            among the South Asian immigrants in Britain, of whom 49.1% had   Awolowo University, Ile-Ife, Osun, Nigeria, Phone: +2348037998247,
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            menstrual irregularity.  About 10% of the diagnosis of PCOS is made   e-mail: akintunds@yahoo.com
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            during gynecologic visits.  Approximately 30–75% are obese, while   How to cite this article:  Fehintola  AO,  Awotunde  OT,  Ogunlaja  OA,
            50% of patients have hirsutism 3                   et al. The Outcome of Laparoscopic Ovarian Drilling in Patients with
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               In Nigeria, Ugwu et al.  and Omokanye et al.  reported   Clomiphene-resistant  Polycystic  Ovarian  Syndrome  in  Ogbmoso,
            prevalence rates of 18.1% and 31%, respectively. In their series,   Nigeria: A Prospective Evaluation. World J Lap Surg 2020;13(3):101–107.
            the majority of the patients presented with infertility and oligo-  Source of support: Nil

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            menorrhea.  PCOS is responsible for about 75% of anovulatory   Conflict of interest: None
            infertility. 6
               PCOS predisposes women to diabetes mellitus, endometrial
            carcinoma, and cardiovascular disease. 7–9
               The exact pathophysiology in PCOS is unknown. However, a   PCOS based on the history and examination findings. According to
            genetic component is likely, since the condition tends to run in families.   an international consensus, the syndrome can be diagnosed using
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            Also, the pattern of inheritance is X-linked dominance.  Furthermore,   the “Rotterdam criteria (presence of at least two of the following
            studies have shown the occurrence of PCOS in approximately 50%   conditions): Oligomenorrhea or amenorrhea, hyperandrogenism,
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            of first-degree relatives.  We can make a presumptive diagnosis of   and polycystic ovaries on ultrasound. Researchers defined the
            © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.
            org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to
            the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain
            Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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