Page 12 - World Journal of Laparoscopic Surgery
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Ganeshselvi Premkumar

            endometrial cells through the fallopian tubes. These cells are  cyclical hematuria, cyclical dysuria, ureteric obstruction, cyclical
            capable of implantation and development. Dissemination to  hemoptysis, cyclical pain and swelling in the umbilicus or scars.
            distant sites is possible by lymphatic and vascular spread. This
            theory remains the most popular and is supported by  PATHOGENESIS OF INFERTILITY IN
            experiments that show that endometrial cells are viable both in  ENDOMETRIOSIS
                2
                           3
            vitro  and in vivo.  The exact mechanism of endometrioma  The nature of the relationship between endometriosis and
            formation is unknown. One possibility is the formation of an  infertility remains controversial. One recent study suggests that
            adhesion between the ovary and pelvic peritoneum and the  the presence of endometriosis alone where no other cause is
            progressive infolding of the ovary forming a pseudo cyst called  found affects fertility.  But the mechanism by which minimal
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            an endometrioma.                                   endometriosis affects fertility in such women is uncertain. It is
               The coelomic metaplasia theory explains the unusual sites
            of endometriosis but evidence for it has yet to be established.  accepted that moderate-severe endometriosis is likely to result
                                                               in infertility because of adhesions disrupting the anatomical
                    4
            Dr Meyer  proposed that coelomic epithelium undergoes  relationships between fallopian tube and ovary. Furthermore,
            metaplasia to become endometriosis. Endometriosis does not  severe dyspareunia and pelvic pain preventing regular sexual
            show the distribution with older age that is found in other organs  intercourse could also affect fertility.
            that undergo metaplasia, e.g. squamous metaplasia in the lung.
               Iatrogenic dissemination can occur during gynecological
            procedures, but it is not clear whether the rate of transplantation  DIAGNOSIS OF ENDOMETRIOSIS
            varies with the time of cycle. Recent work on pathogenesis  A clinical history of pelvic pain, particularly if related to the
            showed immunogenetic defects, e.g. aberrant expression of  menstrual cycle always suggests a diagnosis of endometriosis.
            factor. Steroidogenic Factor-1 activates the expression of the  Examination may reveal tenderness or an adnexal mass.
                            5
            aromatase enzyme  and increased expression of cyclo-  Ultrasound scanning, computerized tomography scan, and
            oxygenase-2 in the stromal cells. 6
                                                               magnetic resonance imaging may assist in the diagnosis, but
                                                               none are highly specific and a normal result does not exclude
            HISTOLOGY OF ENDOMETRIOSIS
                                                               endometriosis.
            The natural history is that endometriosis evolves from type 1 to  However, endometriosis can only objectively be confirmed
            type 3 (Table 1). Type 1 may be more related to infertility and  by visualization. This is mainly done by laparoscopy or
            types 2 and 3 with chronic pain.                   laparotomy. Laparoscopy allows inspection of the entire pelvis
                                                               and the extent of disease recorded using a classification system.
            ANATOMICAL DISTRIBUTION AND SYMPTOMS
                                                               STAGING OF ENDOMETRIOSIS
            The most common site of endometriosis is the ovary (44%).
            The other common sites are peritoneum, ovarian fossa,  Since 1922, various classifications of endometriosis have been
            uterosacral ligaments, uterovesical fold and Pouch of Douglas.  proposed. In the early 1900’s the classification was descriptive.
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            Endometriosis has also been found involving the bladder, ureter,  Huffmann  in 1951 was a pioneer in recommending treatment
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            lung, liver, diaphragms, scars and even brain.     according to the stage of the disease. In 1973, Acosta  laid the
               The symptoms depend on the site. It can present as  foundations for a predictive classification. For the purpose of
            dysmenorrhea, dyspareunia, chronic pelvic pain, infertility,  uniformity in practice, the American Fertility Society (AFS)
            irregular heavy periods, cyclical rectal bleeding, tenesmus,  proposed its first classification of endometriosis in 1979. As


            TABLE 1: Histology of endometriosis
             Histological  Histological appearance  Histological  appearance  Laparoscopic appearance  Response to treatment
             type          Macroscopic           Microscopic

             Type 1       Free growing implant or polyp  Surface epithelium and  Hemorrhagic vesicles or  Hormone responsive
                                                 stroma, with or without  spots
                                                 glands

             Type 2       Enclosed implant       Endometrial glands and  Papules or nodules  Proliferate in response to
                                                 stroma without surface                    hormones
                                                 epithelium
             Type 3       Healed lesions         Glands only          Nodules or a scar    No  response to hormones


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