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Minaya Bravo et al

                Three clear causes have been described like cause of liver  lating heparin like associated to hematological disease such
            hematoma: Small tears of the hepatic capsule after traction on  multiple myeloma or leukaemia. About the management: If the
            the gallbladder, puncture of the liver with the trocar when  patient is stable the hematoma can be observed or drained
            introducing the trocar and parenchymal injury while excision of  percutanously with ultrasound guidance, and if instable
            the gallbladder. 15                                laparotomy is mandatory.
               Others back up that this kind of complication is inherent to  More studies are needed to clear this causes and determinate
            the method of surgery itself. 5                    is some kind of study should be accomplished in patient with
               The diagnostic can be difficult till symptoms appear: Pain,  risk of bleeding, as though the role of the ketorolac.
            fever, vomits or shock hypovolemic.
               About the management: If the patient is stable, asympto-  REFERENCES
            matic and the hematoma is small, a conservative therapy is the
            choice. But if the hematoma has an important size so it is likely  1. Ertad BL, Rapapport WD. Subcapsular hematoma alter
            that it can be reabsorbed, a percutaneous drain can be performed  laparoscopic cholecystectomy, associated with ketorolac
                                                                    administration. Pharmacotherapy 1994;14:613-15.
                                      7
            using under ultrasound guidance.  If the patient is unstable, a  2. Pietra N, Sarli L, Costi R, Violi V. Intrahepatic subcapsular
            laparotomy is mandatory. 6                              hematoma: a rare postoperative complication of laparoscopic
               We report about two cases:                           cholecystectomy. Surg Laparosc Endosc  1998; 8:304-07.
                The first one was a woman with multiple myeloma ( IgA),  3. Vuilleumier H, Halkic N. Ruptured subcapsular hematoma after
            who was given 30 mg intravenous ketorolac during and after  laparoscopic cholecystectomy attributed to ketorolaco induced
            surgery . There were no incidents during surgery and no lesions  coagulopathy. Surg Endosc  2003;17:659.
            were seen. The postoperative recovery was slow with non-  4. Nathason LK, Shimi S, Cuscgieri A. Laparoscopic cholecys-
            specific symptoms. She went under laparotomy because of  tectomy: the Dundee thecnique. Br J Surg 1991;78:155-59.
            hemodynamic instability. We did not find iatrogenic lesions,  5. Alexander HC. Two unusual hemorrhagic complications during
            just an important hematoma in the right hepatic lobe. It was  laparoscopic cholecystectomy. Surg Laparosc Endosc.
            drained and a packing made.                             1993;3:346-48.
                The cause about this intrahepatic hematoma is not clear.  6. Obara K, Imai S, Uchiyama S, Uchiyama K, Moriyama Y. A
                                                                    case with subcapsular hematoma of the liver following
            We think that ketorolac could have had a role, or have aggra-  laparoscopic cholecystectomy. Nippon Ika Daigaku Zasshi.
            vated some small lesions caused during surgery and not seen.  1998 Dec; 65:478-80.
            In addition to, the patient had a multiple myeloma; the role of  7. Bhandakar DS, Katara AN, Shah RS. Intrahepatic subcapsular
            this is not clear because it was studied by hematologists and till  hematoma complicating laparoscopic cholecystectomy. Sug
            now they have not been able to demonstrated alteration in  Laparosc Endosc. 2004; 18(5):868-70.
            coagulation tests. We think that more studies about this  8. Geeta S, Shetty J. Stuart Falconer, Hakim Benyounes.
            condition are needed because of  some cases, in the literature,  Subcapsular hematoma of the liver fater laparoscopic chole-
            about bleeding in this patients. We cannot discard the breaking  cystectomy.  Journal of laparoscopic and advanced surgical
            of some hemangioma during surgery though no hemangioma  thecniques 2005;15(1):48-50.
            were seen in ultrasound previous to surgery.         9. Benoît Navez, Didier Mutter, Yves Russier, Michel Vix, Faek
               In the second case, ketorolac was also administrated during  Jamali, David Lipski, et al. Safety of Laparoscopic Approach
            and after surgery, 30 mg each 8 hours, intravenous. There were  for Acute Cholecystitis: Retrospective Study of 609 Cases.
                                                                    World Journal of Surgery 2001;25(10):1352-56.
            no incidents during surgery. Laparotomy was needed because  10. Laporte JR, Ibanez L, Vidal X, Vendrell L, Leone R. Upper
            of hemodynamic instability. But in this case, the cause seems  gastrointestinal bleeding associated with the use of NSAIDs:
            to be a few more clear image of 2 cm of size compatible with a  newer versus older agents. Drug Saf 2004;27(6):411-20.
            hemangioma was found in an ultrasound during the follow-up.  11. Jensen K, Kehlet H, Lund CM. Postoperative recovery profile
            We think that the hemangioma could have been broken fortui-  after laparoscopic cholecystectomy: a prospective observational
            tously during surgery and not seen, and the ketorolac given  study of a multimodal anesthetic regime. Acta Anaesthesiol Scand.
            would have aggravated the lesion, like Pietra et al. supports in  2007;51(4):464-71.
            his work. 2                                         12. Shetty GS, Falconer JS, Benyounes H. Subcapsular hematoma
               We conclude, the LC is a safe method and the choice for  of the liver after laparoscopic cholecystectomy . J Laparoendosc
            symptomatic uncomplicated cholelithiasis, with low mortality  Adv Surg Tech A 2005;15(1):48-50.
            and morbidity. The presence of a subcapsular liver hematoma  13. Llamas P, Outeirino J, Espinoza J, Santos AB, Roman A, Tomas
            after a LC is a rare complication few studied. Till now only 10  JF. Report of three cases of circulating heparin-like anti-
            cases have been reported. It has been connected to adminis-  coagulants.  Am J Hematol 200;67(4):256-58.
            tration of ketorolac, which would aggravate small iatrogenic  14. Torjemane L, Guermazi S, Ladeb S, Romdhane NB, Lakhal A,
                                                                    Abdelkefi A, et al.  Blood Coagul Fibrinolysis. 2007;18(3):
            lesions occurring during surgery and that would go unnoticed.  279-81.
            But other factors could have an important role, like the presence  15. Fusco MA, Scout TE, Pauluzzi MW. Traction injury to the
            of hemangiomas that would be ruptured by chance during  liver during laparoscopic cholecystectomy. Surg Laparosc
            surgery or causes that would produce bleeding such as circu-  Endosc 1994;6:454-56.

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