Page 38 - World Journal of Laparoscopic Surgery
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Ultrasonic Dissection vs Conventional Method
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               Jain et al.  in his prospective randomized control study reported   The postoperative fall in hemoglobin was significantly less in
            significantly less time to remove GB from its bed using ultrasonic   the CLC group (0.40 g/dL vs 0.70 g/dL; p 0.001), though there was no
            shears (nearly 4 minutes vs 7.36 minutes with electrocautery, p   incidence of clinically significant (severe) bleeding in either group
            0.001). We had similar experience, though it was not statistically   requiring blood transfusion, the sole reason for conversion. The
            significant in our study. The difference is because ultrasonic shear   conversion requirement was more because of the difficult anatomy,
            is all in one tool for the procedure (dissection, ligation of the duct   not solely because of bleeding. This significant difference may be
            and artery, and removal of GB from the liver bed). Besides, ultrasonic   because of minor to moderate bleeding in the CL group. On the
            device has been said to produce small vacuoles or cavitation which   contrary, ultrasonic shear is known for hemostasis. It coagulates
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            enlarge and separate the tissue,  making it easy to separate the   before separating the tissue and stays between the planes, so there
            GB from the GB bed. Even in the case of inflammation where the   is decreased bleeding and oozing from the surfaces.
            tissue is tougher, vascular, and more fibrous, the ultrasonic energy   No surgery is without complication. Laparoscopic
            and its hemostatic ability keep the operative field clear, decreasing   cholecystectomy is the most common elective surgery being
            the operative time and avoiding inadvertent injuries.  performed worldwide, and research has proved its perfection
               The CLC group demonstrated less need for drainage. The   to avoid associated complications. Clipless laparoscopic
            decreased drain placement led to reduced pain scores, early   cholecystectomy is one of the techniques that needs to be
            discharge, and decreased morbidity. The drain was placed   addressed. As with any new procedure, fear and hesitancy to
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            according to the operative surgeon’s preference. It was kept for   adopt this noble technique can be observed. Hüscher et al.
            those who had bleeding/oozing, bile stain, or in difficult dissections.   has histologically confirmed the effective sealing of the cystic
            In our study, the drain was removed mostly within 48 hours (median   duct stump by the harmonic shears. Post LC bile leak can give
            2 days) though few of our patients required a prolonged drainage.   the surgeon sleepless nights. This can be the main reason why
            Less need for abdominal drain in the CLC group is also one of the   most of the surgeons hesitate to perform CLC. This myth has been
            contributing factors for less operative time and morbidity.  challenged in the recent days, providing better outcome and sound
               The reported conversion to open cholecystectomy rate in   sleep for surgeons. By using ultrasonic shear closure, division of
            the literature is 1.2–8.2%. 13,22–24  We had three (2.6%) conversions,   vessels up to 5 mm can be done safely. 2,14,29–37  We had a total of
            one (1.85%) in the CLC group and two (3.2%) in the CL group.   6.25% morbidity following the surgery; however, no mortality
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            Conversion rate in the prospective study by Hüscher et al.  was even   was reported in either group. Two (3.77%) patients had morbidity
            lower (0.87%) than that in the literature and showed theoretical   in the CLC group and five (8.47%) in the CL group (p 0.44). Three
            benefits of ultrasonic dissection. The reasons for conversion in   (2.67%) patients in our study had bilious drainage, one (1.88%) in
            different studies 2,22,25,26  varied between the two subgroups, i.e.,   the CLC group and two (3.38%) in the CL group. All were managed
            surgeon in training and expert. But, in general, conversion was   with drains and none required further interventions. In the present
            due to the dense adhesion/frozen Calot’s triangle, intraoperative   study, one case in the CLC group (1.88%) had port site infection
            complications, difficult anatomy, or inability to identify the   and two cases (3.38%) in the CL group had port site infection and
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            structures. Difficult anatomy of the Calot’s triangle was the only   a single case (1.69) had chest infection. Bessa et al.’s  finding also
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            reason for 4% conversion rate in the study by Jain et al.,  and   did not report any bile leak in either group, demonstrating the
            it was equal in both the groups. Our reason for conversion in   effectiveness of harmonic shears in closing the duct as safely as with
            the CL group was obscured anatomy and bleeding, and another   the application of metallic clips. This capability, safety, and efficacy
            case had dilated CBD with multiple calculi requiring an open   of harmonic shears in sealing and dividing the cystic duct without
            choledochoduodenostomy.                            increasing the complication rate also have been demonstrated in
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               Alexander  has extensively described the causes of pain   other studies. 2,10,20  In the present study, as well as in the Westervelt
            after laparoscopy. The major cause of post laparoscopic pain was   and Bessa et al. 10,20  studies, the harmonic shears were applied to
            attributed to the sudden distension/stretching of the peritoneum,   only one side of the cystic duct where sealing and division were
            leading to the traumatic traction of the nerves, vessel injury, and   achieved, with no bile leaks from the cystic duct stump encountered
            release of the inflammatory mediators. In addition, phrenic nerve   in any of the two studies. So the double application of the harmonic
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            irritation due to gas used for the pneumoperitoneum was pointed   shears to the cystic duct as explain by Hüscher et al.  may be
            out to be responsible for the prolonged persistence of shoulder   unnecessary and an unsafe practice. 2,10,20  Lateral energy spread is
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            tip pain.  The use of ultrasonic shear led to (a) minimal lateral   the other mechanism for bile duct injury. Unlike the CL group which
            thermal injury, minimal damage to the surrounding nerves, and   witnessed high chances of lateral thermal injury to the bile duct,
            minimal tissue charring, and, therefore, minimal inflammation and   ultrasonic instruments cause negligible lateral damage. 36,37  In the
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            less release of inflammatory mediators;  (b) decreased operative   present study, the low incidence of the bile duct leak or injury in
            time contributing to less pneumoperitoneum-related peritoneal   the CLC group (1.88%) is not only comparable to the CL group but
            distension. This may have accounted for low pain score in the   also within the acceptable range of bile duct injury following LC.
            CLC group. The significant difference in pain scores was obtained   Also, the leak that we had in the CLC group was a minor duct injury,
            between the two groups in the first 12 hours and it was more with   which was managed successfully with pigtail catheter.
            the CL group (p < 0.01). No significant differences were obtained   Most of the patients in our study were discharged on the
            in the pain scores in the first week after surgery. The postoperative   first postoperative day following surgery and was not significant
            analgesic requirement was less in the ultrasonic shear group   between the groups (p 0.23), though there was significantly less
            compared with the electrocautery group (1.89 vs 2.66; p 0.001) in   hospital stay in the ultrasonic group in other studies. 2,12  Shorter
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            the study by Jain et al.,  but in our study analgesic requirement in   duration has been attributable to the less number of patients
            both the groups was similar, which may be because patients were   requiring drainage and less incidence of GB perforation, leading
            given analgesia even when they had low pain score on their demand.  to localized peritonitis and less pain.


            124   World Journal of Laparoscopic Surgery, Volume 12 Issue 3 (September–December 2019)
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