Page 36 - World Journal of Laparoscopic Surgery
P. 36
Hana Alhomoud, Mohamed Abdelmohsen
than that of common open cholecystectomy, illustrating
that XGC creates difficulty in operation.
Although XGC is a benign change of the GB with a low
13
mortality rate, patients with XGC usually have a longer
hospital stay than those with cholecystitis who undergo
cholecystectomy and more postoperative complications,
including leakage of bile, bile peritonitis, GB bleeding,
hepatic abscess, infection of the incisional wound, and
cholangitis stenosis. This is largely related to difficulty in
stripping the GB, the mode of operation, and the physical
condition of the patient. 7
In spite of difficulty in surgical treatment of XGC,
the operation can be carried out successfully as long as
Fig. 2: High-power microscopic picture. Collections of foamy clinicians have a sound knowledge of the anatomical
histiocytes mixed with lymphocytes
structures of the GB, make an accurate intraoperative
diagnosis, and choose the proper mode of operation.
5-8
it occurs mostly in middle-aged and old persons. The
low incidence of XGC sometimes leads to misdiagnosis CONCLUSION
by clinicians. Differentiating XGC from GB cancer is a diagnostic
No symptoms and signs are specific for XGC; they are dilemma. Making this distinction preoperatively or
9
similar to those of acute or chronic cholecystitis. In this intraoperatively is difficult. The presence of firm adhe-
case report, the patient had the symptoms in the right hypo- sions of the GB to neighboring organs and tissues,
chondrial region and suffered from radiating pain in the thickened GB wall together with gallstones in a patient
shoulder and back, nausea, vomiting, and fever. Yet, some with chronic disease is highly suggestive of XGC. A
10
4
features on US and CT were highly suggestive of XGC, definitive diagnosis still necessitates a histopathological
including thickening of the GB wall, GB stone shadow, and examination.
adhesion to neighboring tissues and organs. Despite all
these distinctions, it is difficult to differentiate XGC from REFERENCES
carcinoma of the GB clinically. 11,12 In this study, US mis-
diagnosed this case of XGC as carcinoma of the GB, while 1. Houston JP, Collins MC, Cameron I, Reed MW, Parsons MA,
CT is not, indicating a fairly high misdiagnosis rate, which Roberts KM. Xanthogranulomatous cholecystitis. Br J Surg
1994 Jul;81(7):1030-1032.
may be related to the low incidence of XGC as well as insuf- 2. Lichtman JB, Varma VA. Ultrasound demonstration of
ficient experience of clinicians. Chronic inflammation in xanthogranulomatous cholecystitis. J Clin Ultrasound 1987
XGC causes persistent thickening of the GB wall, adhesions Jun;15(5):342-345.
to adjacent tissues and organs, and in some cases, Mirizzi 3. Casas D, Pérez-Andrés R, Jiménez JA, Mariscal A, Cuadras P,
2
syndrome was found. In other cases, an internal fistula Salas M, Gómez-Plaza MC. Xanthogranulomatous chole-
13
forms between the GB and a neighboring viscous. In this cystitis: a radiological study of 12 cases and review of the
literature. Abdom Imaging 1996 Sep-Oct;21(5):456-460.
case report, the major intraoperative findings included 4. Kim PN, Ha HK, Kim YH, Lee MG, Kim MH, Auh YH. US
thickening of the GB wall and adhesions of the GB to findings of xanthogranulomatous cholecystitis. Clin Radiol
adjacent tissues and organs. In addition, cholecystolithiasis 1998 Apr;53(4):290-292.
was found in our case, in accordance with the incidence 5. Eriguchi N, Aoyagi S, Tamae T, Kanazawa N, Nagashima J,
13
rate in most reports (85 to 100%). Cholecystectomy is the Nishimura K, Hamada S, Kawabata M, Kodama T. Xan-
first choice for XGC, either complete or partial. Dissection thogranulomatous cholecystitis. Kurume Med J 2001;48(3):
219-221.
should not proceed by force and the excision range should 6. McCoy JJ Jr, Vila R, Petrossian G, McCall RA, Reddy KS.
not be blindly extended in order to avoid injuries to the Xanthogranulomatous cholecystitis. Report of two cases. J S
extrahepatic bile duct and neighboring organs. Special C Med Assoc 1976 Mar;72(3):78-79.
attention should be paid to cases where internal fistula or 7. Guzman-Valdivia G. Xanthogranulomatous cholecystitis
Mirizzi syndrome is found and biliary injuries should be in laparoscopic surgery. J Gastrointest Surg 2005 Apr;9(4):
494-497.
7
avoided. Analysis of data from outside of China shows that 8. Cardenas-Lailson LE, Torres-Gomez B, Medina-Sanchez S,
in 65% of XGC cases, complete cholecystectomy was dif- Mijares-Garcia JM, Hernandez-Calleros J. Epidemiology
ficult and 35% of them underwent partial cholecystectomy. of xanthogranulomatous cholecystitis. Cir Cir 2005 Jan-
In our study, the mean duration of operation was longer Feb;73(1):19-23.
78