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                                                                                10.5005/jp-journals-10033-1309
                                                                                   Xanthogranulomatous Cholecystitis
          CASE REPORT

          Xanthogranulomatous Cholecystitis

                          2
          1 Hana Alhomoud,  Mohamed Abdelmohsen

          ABSTRACT                                            biliary radicles, possibility of cholangiocarcinoma as

          Xanthogranulomatous cholecystitis is a rare, benign, chronic   described by sonarist and suggestion of cholecystitis
          inflammatory disease of the gallbladder (GB). Its importance lies  with fluid collection in CT conclusion. The patient had
          in the fact that imaging studies and intraoperative appearance  endoscopic retrograde cholangiopancreatography with
          may mimic tumor of the GB. Xanthogranulomatous cholecystitis   papillotomy and sweeping to the CBD with balloon
          is difficult to diagnose pre- or intraoperatively and remains a
          challenge in medical practice. The definitive diagnosis depends   catheter, with small amount of pus coming from the GB
          on the histopathologic examination.                 as described by the interventional radiologist.
                                                                 Laparoscopic cholecystectomy was started, which
          Keywords: Gallbladder cancer, Surgery, Xanthogranulomatous
          cholecystitis.                                      was converted to open cholecystectomy. The GB wall
                                                              was thickened and the serosa was surrounded by dense
          How to cite this article: Alhomoud H, Abdelmohsen M. Xantho-
          granulomatous Cholecystitis. World J Lap Surg 2017;10(2):77-79.  fibrous adhesions, which were attached to adjacent
                                                              hepatic parenchyma and transverse colon. There was a
          Source of support: Nil
                                                              small-sized abscess in the GB wall. Dissection between
          Conflict of interest: None                          the GB serosa and hepatic parenchyma was difficult
                                                              leading to subtotal cholecystectomy. Cross-section
          INTRODUCTION                                        through the wall revealed multiple yellow-colored,
                                                              nodule-like lesions, and there were also multiple black-
          Xanthogranulomatous cholecystitis (XGC) is an uncom-  pigmented gallstones.
          mon variant of chronic cholecystitis characterized by   The pathologic findings showed the collections of
          the presence of grayish yellow nodules or streaks in   foamy histiocytes containing abundant lipid in the cyto-
          the gallbladder (GB) wall, mainly caused by lipid-laden   plasm and admixed lymphoid cells. Histologically, it was
                       1
          macrophages.  Although well-defined pathologically,   confirmed as XGC.
          XGC still remains difficult for the radiologist to recognize   The picture of XGC is shown in Figures 1 and 2.
          because some of the sonographic and computed tomogra-  The patient was discharged on postoperative day 10
                  2-4
          phy (CT)  features of the disease are nonspecific, such as   without complications.
          GB wall thickening and calculi. This case report describes
          the clinical, sonographic, and CT findings in one patient   DISCUSSION
          with histologically diagnosed XGC.
                                                              Xanthogranulomatous cholecystitis was first reported
          CASE REPORT                                         and named by McCoy et al, with a low incidence, merely
                                                              0.7 to 13.2% of all inflammatory diseases of the GB, and
          A 59-year-old male with a history of chronic calcular
          cholecystitis, type II diabetes mellitus was admitted
          to Al-Sabah Hospital, Kuwait, with a 2-day history of
          abdominal pain and jaundice.
             Abdominal ultrasound (US) and CT abdomen were
          done, which revealed distended GB with concentric
          lobulated wall thickness (1.1 cm) with mud seen within
          it, dilated common bile duct (CBD), dilated intrahepatic



           1 Consultant,  Registrar
                     2
           1,2 Department of Surgery, Al-Sabah Hospital, Kuwait City, Kuwait
           Kingdom of Saudi Arabia
           Corresponding Author:  Hana  Alhomoud,  Consultant
           Department of Surgery, Al-Sabah Hospital, Kuwait City, Kuwait
           Kingdom  of  Saudi Arabia,  Phone:  +966551440610,  e-mail:
           hana_alhomoud@hotmail.com                           Fig. 1: Low-power microscopic view of ulceration of epithelium
                                                                           with underline lobulated lesion
          World Journal of Laparoscopic Surgery, May-August 2017;10(2):77-79                                77
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