Page 44 - World Journal of Laparoscopic Surgery

Reduction of Vomiting after Laparoscopic Cholecystectomy
Other findings of the study indicate that there is a significant 3. Akhoundzadeh R, Mohtadi AR, Nesioonpour S, et al. Evaluation of the
correlation between nausea and vomiting in 6 and 24 hours effect of injection of bupivacaine in reducing nausea and vomiting
after surgery in the aprepitant group and the aprepitant and after laparoscopic cholecystectomy surgery. Jundishapur Sci Med J
ondansetron group simultaneously. This result shows the ability to 2013;12(3):307–312.
predict the severity of nausea and vomiting 24 hours after surgery 4. Jafari M, Molavi B, Shojaiefard A, et al. Postoperative pain relief
following bupivacaine injection in sites & intraperitoneal spray
based on the severity of nausea and vomiting 6 hours after surgery. of laparoscopic cholecystectomy. J Pharm Res Int 2017;19(4):1–7.
In the event of severe symptoms at 6 hours, the symptoms may be DOI: 10.9734/JPRI/2017/36222.
more severe at 24 hours. But in general, the severity of symptoms 5. Miller RD. Miller’s Anesthesia, 6th ed. Churchill, Livingstone: Elsevier;
at 24 hours is less than 6 hours. 2005. p. 68, 71. Ku CM, Ong BC.
In a study by Se-Jin Lee et al., they evaluated the effect of 6. Sahabi SM, Al Reza H, Alijanpour E, et al. Comparison of dexamethasone
aprepitant in preventing postoperative nausea and vomiting in and ondansetron with dexamethasone and metoclopramide in
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difference between the aprepitant and the control group at 6 and 2009;53(2): 73–78.
24 hours, while the incidence of nausea and vomiting in the aprepitant 7. Sinha AC, Singh PM, Williams NW, et al. Aprepitant’s prophylactic
efficacy in decreasing postoperative nausea and vomiting in
group was less than the control group. At 6–24 hours, the incidence morbidly obese patients undergoing bariatric surgery. Obes Surg
14
was less than the first 6 hours, which is consistent with our study. 2014;24(2):225–231. DOI: 10.1007/s11695-013-1065-1.
Diemunsch et al., in their study, compared aprepitant with 8. Apfel CC, Malhotra A, Leslie JB. The role of neurokinin-1 receptor
ondansetron for the prevention of postoperative nausea and antagonists for the management of postoperative nausea and
vomiting in major abdominal surgery. They indicated that aprepitant vomiting. Curr Opin Anaesthesiol 2008;21(4):427–432. DOI: 10.1097/
is more effective than ondansetron in reducing nausea incidence on ACO.0b013e328301831c.
the first day following surgery, which is consistent with our study. 16 9. Jamshid S, Mousavi A, Mohammad Reza S, et al. The effect of
Another study by Vallejo et al. assessed aprepitant in reducing dexamethasone on the reduction of nausea and vomiting after
thymppanomastoidectomy. J Tehran Univ Med Sci 2014;16(1):
postoperative nausea for 48 hours in patients undergoing plastic 9–13.
surgery. The results demonstrated the severity of nausea was 10. Entezariasl M, Isazadehfar K, Noorani Z. The comparison effect of
significantly higher ondansetron group comparing with the preoperative ondansetron and metoclopramide in reducing nausea
ondansetron plus aprepitant group, which is in the same way with and vomiting after laparoscopic cholecystectomy. J Ardabil Univ Med
our study. 17 Sci 2013;13(2):155–163.
11. Akhoundzadeh R, Mohtadi A, Nesioonpour S, et al. Evaluation of the
effect of injection of bupivacaine in reducing nausea and vomiting
conclusIon after laparoscopic cholecystectomy surgery. J Shiraz Univ Med Sci
In patients undergoing laparoscopic cholecystectomy with general 2016;12(3):10–14.
anesthesia, ondansetron, and aprepitant can be used to reduce 12. Mortazavi Y, Nikbakhsh N, Alijanpour E, et al. Effect of metoclopramide
postoperative nausea and vomiting, while the effect of aprepitant and ondansetrone plus dexamethason on postoperative nausea and
on this complication is greater than ondansetron. If these two drugs vomiting in cholecystectomy laparoscopic surgery. J Gorgan Univ
Med Sci 2014;16(1):9–13.
are used concurrently, they will have a longer and much more 13. Isa Zadeh Far, Memory, Expectant, Fahim. Comparison of the effect
efficacy than their separate injections. of preoperative ondansetron and dexamethasone on the prevention
of nausea and vomiting after laparoscopic cholecystectomy.
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AcknowledgMents 14. Lee SJ, Lee SM, Kim SI, et al. The effect of aprepitant for the
We would like to thank all personnel in the general operating room prevention of postoperative nausea and vomiting in patients
and surgical ward for their contribution to this study. undergoing gynecologic surgery with intravenous patient controlled
analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron
dIsclosure alone. Korean J Anesthesiol 2012;63(3):221–226. DOI: 10.4097/
kjae.2012.63.3.221.
Ethical Approval Statement 15. Green MS, Green P, Malayaman SN, et al. Randomized, double-blind
All procedures performed in the study involving human participants comparison of oral aprepitant alone compared with aprepitant and
were in accordance with the ethical standards of the institutional transdermal scopolamine for prevention of postoperative nausea
and/or national research committee and with the 1964 Helsinki and vomiting. Br J Anaesth 2012;109(5):716–722. DOI: 10.1093/bja/
aes233.
declaration and its later amendments or comparable ethical 16. Diemunsch P, Gan TJ, Philip BK, et al. Single-dose aprepitant vs
standards. ondansetron for the prevention of postoperative nausea and
vomiting: a randomized, double-blind phase III trial in patients
Informed Consent Statement undergoing open abdominal surgery. Br J Anaesth 2007;99(2):
Informed consent was obtained from the participants included in 202–211. DOI: 10.1093/bja/aem133.
the study. 17. Vallejo MCAL, Ibinson JW, Barnes LR, et al. Aprepitant plus
ondansetron compared with ondansetron alone in reducing
postoperative nausea and vomiting in ambulatory patients
references undergoing plastic surgery. Plast Reconstr Surg 2012;129(2):519–526.
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16143.4D.

42 World Journal of Laparoscopic Surgery, Volume 14 Issue 1 (January–April 2021)