In this video, we assessed the feasibility of total laparoscopic hysterectomy (TLH) in cases of very large uterus weighing more than 9500 grams. We have analyzed whether it is possible for an experienced laparoscopic surgeon to perform an efficient total laparoscopic hysterectomy for large myomatous uteri regardless of the size, number, and location of the myomas. Total laparoscopic hysterectomy is a technically feasible procedure. It can be performed by experienced surgeons for large uteri regardless of the size, number, or location of the myomas.