This video demonstrate How to Perform Safe Laparoscopic Duodenal Perforation - Lecture by Dr R K Mishra. Despite the great advances in laparoscopic techniques, most active general surgeons do not apply laparoscopic surgery in the treatment of duodenal ulcer perforation when facing a real-life emergency. Therefore, our this presentation is designed to evaluate the feasibility of laparoscopic surgery in duodenal ulcer. Repair of duodenal perforation by Graham patch plication was described in 1937 represents an excellent alternative approach. Perforated duodenal ulcer is a surgical emergency. In 1990 Mouret et al. reported the first laparoscopic sutureless fibrin glue omental patch for perforated duodenal ulcer.