This video demonstrate Harmonic Scalpel presented by Dr R K Mishra. The Harmonic scalpel is basically an ultrasonic generator. Harmonic Scalpel is a surgical instrument used to simultaneously cut and coagulate tissue. Unlike Electrosurgery, the harmonic uses ultrasonic vibrations instead of electric current to cut and cauterize tissue. Benefits of the Harmonic Scalpel. The Harmonic Scalpel's biggest advantage is the reduced bleeding and recovery time for the patient. Other advantages include the ability for a surgeon to make more precise cuts, and an overall reduction of lateral thermal tissue damage in comparison to other operating devices. A Harmonic scalpel cuts via vibration. The scalpel surface itself cuts through tissue by vibrating in the range of 55,500 Hz. The high frequency vibration of tissue molecules generates stress and friction in tissue, which generates heat and causes protein denaturation.