This video demonstrates Laparoscopic Hysterectomy By Ligation of Uterine Artery by Mishra's Knot and Vault Closure by Weston Knot. In this procedure, Appendectomy was also performed. Today, lap hysterectomy is a safe and feasible technique to manage benign uterine pathology as it offers minimal postoperative discomfort, shorter hospital stay, rapid convalescence, and early return to the activities of daily living. Considerable technical advances in this procedure have occurred during the last few years. One of the best practice of performing laparoscopic hysterectomy is to ligate the uterine artery. The vascular supply of the uterus is mainly derived from the uterine and ovarian arteries. Because most blood enters the uterus through the uterine arteries, transient uterine ischemia occurs after uterine artery ligation. Bilateral uterine vessel ligation is an efficient method to obliterate the blood flow to the uterus.