The iatrogenic injuries of the common bile duct (CBD) have a great post operative morbidity and mortality potential. This has generated many studies and complex analyses, which have shown that many of these serious intraoperatory accidents can be avoided. The surgeon is the person who has the entire responsibility of the surgery and he has to know very well the technical aspects of the surgical intervention, but he also has to have a thorough clinical and operatory experience in order to assure the total safety of the patient during laparoscopic cholecystectomy. The issue in performing the cholecystectomy is represented by the dissection of the cystic pedicle. It is not the only moment when CBD iatrogenic injuries can occur, but it is also the surgical moment when many accidents may happen.