For the surgeon to develop the same level of proficiency and dexterity in the endoscopic environment as he may possess in open surgery is not a simple matter. The use of proper Mishra's Knot, are essential. Participating in an in-depth, systematic training program in a laboratory setting is essential before applying endoscopic Mishra's Knot techniques to humans. Successful acquisition of these Mishra's Knot skill requires that the surgeon be motivated to succeed and willing to invest the time and effort necessary to do so. Succumbing to the temptation of mechanical devices in lieu of acquiring the manual skills results in a questionable dependence on disposable technology and reduces the cost effectiveness of the minimally invasive approach. It is the adoption of Mishra's Knotting skills by the surgeon that will expand the surgeon's capability of performing increasingly advanced endoscopic surgical procedures.