This video demonstrates Difficult Laparoscopic Cholecystectomy for Large Stone for Chronic Cholecystitis. Gallstone disease is very common, but a gallstone bigger than 5 cm in diameter is very rare. It is very challenging to be removed by laparoscopic cholecystectomy (LC) and poses extra difficulty in an emergency. The risk of conversion is related to surgeon factors, patient factors, and possibly equipment factors.3 Although the surgeon's experience is very important, the inflammatory gallbladder, emergency operation, comorbidities, increasing age, and male patients are all significant predictors of conversion to open cholecystectomy. Giant gallstone of the size more than 5 cm in diameter is rare, laparoscopic cholecystectomy for these cases would be tried; emergency laparoscopic cholecystectomy can be successfully performed with clear exposure of the anatomy of the Calot's triangle. Accurate preoperative gallstone size measurement could help predict a high risk of converting Laparoscopic Cholecystectomy to open cholecystectomy.