Aprepitant is very much useful for nausea and vomiting after laparoscopic surgery
Wed - December 12, 2012
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A hundred and twenty female patients (ages 21-60) undergoing laparoscopic hysterectomy were randomly used on receive 80 mg (A80 group, n = 40) or 125 mg aprepitant (A125 group, n = 40) or placebo (control group, n = 40) orally 2 h before anesthesia induction. Anesthesia was maintained with isoflurane and remifentanil, and PCA IV using fentanyl and ketorolac were shipped to 48 h after surgery. Incidences of nausea, vomiting/retching, and make use of of rescue antiemetics were recorded at 2, 24, and 48 h after surgery. Complete response was understood to be no PONV with out requirement for rescue treatment. The incidence of complete response was significantly reduced in the A80 and A125 groups than in controls, 56 % and 63 %, vs. 28 %, respectively, P = 0.007 and P = 0.003, respectively, through the first 48 h, and Sixty-five percent and Sixty-five percent vs. 38 %, respectively, both P = 0.025, throughout the first 2 h.
However, there are no statistically significant differences between A80 and A125 groups within the incidences of complete response and PONV during the study period. Conclusions Aprepitant 80 mg orally was great at reducing the incidence of PONV in the first 48 h after anesthesia in patients receiving fentanyl-based PCA after gynecological laparoscopy
