Page 68 - World Journal of Laparoscopic Surgeons
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Sugandha Agarwal
             The aim of this review is to appraise the available  RESULTS
          literature on RA-LESS myomectomy and comment on the   Lewis et al  were the first to publish their experience
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          feasibility, reproducibility, and learning curve as well as   with robotic single-site myomectomy using the da Vinci
          financial implication of this technique.
                                                              Si Surgical System in four patients. This was followed by
                                                              a step-by-step tutorial of their technique and results from
          MATERIALS AND METHODS
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                                                              their first series of 10 women.  Consecutively, in 2017, two
          An electronic search was conducted using relevant key-  studies were published; one was a retrospective analy-
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          words and Mesh terms like single port, single incision,  sis of 61 cases by Choi et al  and another a prospective
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          single site, laparoscopic myomectomy, robotic assisted.  cohort of 21 patients by Gargiulo et al.  Comparison of
          PubMed, Google Scholar, and Cochrane central register for  the outcomes is listed in Table 1.
          controlled trials databases were searched to identify perti-  Most of the patients in all the studies had a high
          nent studies from 2010 to 2017. Studies where hybrid tech-  body mass index (BMI). The mean size of the largest
          niques, that is, robotic assistance combined with any other  myoma that was enucleated was 6.73 ± 2.04 cm by Choi
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          technique like conventional single site/multiport, mini  et al  and 5.7 ± 1.9 by Gargiulo et al  and the largest
          laparotomy were not included. As RA-LESS is a relatively  myoma stood at 12.8 cm in diameter. Maximum number
          newer technique, it was decided to include case studies, case  of myomas removed from a single patient was 12. All
          series, retrospective as well as prospective cohort studies for  types including intramural, submucosal (International
          analysis. Statistical Package for the Social Sciences software  Federation of Gynecology and Obstetrics 2), subserosal,
          was used for statistical analysis where required.   broad ligament, and retroperitoneal as well as anterior,


                                             Table 1: Comparison of included studies
           Study                  Lewis et al 15     Gargiulo et al 16  Choi et al 17      Gargiulo et al 18
           Type                   Case series        Surgical video tutorial  Retrospective analysis  Prospective cohort
           Technique used         da Vinci RA-LESS with  da Vinci RA-LESS with  da Vinci single site   da Vinci with standard
                                  semirigid instruments  semirigid instruments  platform with specialized  rigid instruments in
                                                                       silicone port       coaxial arrangement
           Surgeon learning curve  Surgeon with >8 years  Not mentioned  >200 cases of robotic   Not mentioned
                                  experience with da                   surgery and certification
                                  Vinci, and >1 year with              program in robotic
                                  RA-LESS                              single-site surgery
           Number of patients     4                  10                61                  21
                    2
           BMI in kg/m  (mean ± SD,   30.75 (25–35)  Not mentioned     22.29 ± 4.05 (17.63–38)  29.4 ± 4.7
           range)
           Total operative time in min   Median 210 (202–254)  Median 202 (141–254) 135.98 ± 59.62 (60–295) 154.2 ± 55.2
           (mean ± SD, range)
           Blood loss in mL (mean ±   Median 103 (75–300)  Median 87.5 (10–300)  182.62 ± 153.02   57.9 ± 53.7
           SD, range)                                                  (10–600)
           Largest myoma size in cm   Not mentioned  Median 6 (4–8)    6.73 ± 2.04 (3.0–12.8)  5.7 ± 1.9
           (mean ± SD, range)
           Myoma weight in gm     106.4 (45.0–160.4)  Median 70 (26–154)  Not mentioned    81.6±51
           (mean ± SD, range)
           Maximum number (range)  7 (2–7)           8 (1–8)           12 (1–12)           8 (1–8)
           Skin incision length in cm   Not mentioned  Not mentioned   2.70 ± 0.19 (2.4–3.10)  Not mentioned
           (mean ± SD, range)
           Intraoperative complication  None         None              None                None
           Intraoperative conversion  None           None              None                None
           Duration of hospitalization   <24 hour    Not mentioned     4.21 ± 0.84 (3–6)   0.57 ± 0.87
           in days
           Early/late postoperative   Temporary urinary   None         None                Small bowel
           complication           retention—one                                            obstruction—one
                                  At 4 weeks—none                                          Superficial cellulitis—one
           Patient perception of   Satisfied         Not mentioned     Not mentioned       Not mentioned
           cosmetic appearance
           Financial implication  Not mentioned      Not mentioned     Not mentioned       Difference of $450
                                                                                           between RA-LESS and
                                                                                           its multiport counterpart
           SD: Standard deviation
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