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Laparoscopic vs Mini-incision Open Appendectomy
            The results of this study were comparable with results of the study   LA group, 31 patients resumed their normal activity by 1 week while
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            conducted by Naraintran et al.  and Kushwah et al.  In this study,   16 patients returned to normal work between 1–2 weeks (p <0.001).
            the assessment of the postoperative pain was done by using VAS   Our results were in agreement with the results of the studies by
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            on day 1 at 6, 12, and 24 hours after surgery followed by further   Islam et al.,  Kushwa et al.,  and Shaikh et al. 22
            assessment on day 2, 1 week, 2 weeks, 3 weeks, and then 4 weeks
            after surgery. The postoperative pain score was less in LA group as   conclusIon
            compared to MIA group and was statistically significant in favor of
            LA group. This study was comparable with the results of Naraintran    We conclude that LA is safe and minimally invasive procedure
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            et al.  Kushwah et al.,  and Shaikh et al.  In this study, total   for the management of appendicitis. The main advantages of
            analgesia required in postoperative period was assessed and   LA are less intraoperative time, less pain, less analgesic need,
            calculated as the average number of analgesic injections needed   early recovery, quick resumption of routine activities, and better
            by each patient during the first 24 hours and the need for analgesic   cosmetic results.
            tablets after 24 hours. The difference was statistically significant in
            favor of LA as the average number of analgesic injections needed   Acknowledgments
            was 2.05 in MIA group as compared to 1.41 in LA group. The   The authors acknowledge the immense help received from the
            statistically significant difference was also seen in the number of   scholars whose articles are cited and included in references of
            oral analgesic tablets needed by the patients at home. It was 5.3   this manuscript. The authors are also grateful to authors/editors/
            for the MIA group and 3.2 for the LA group.        publishers of all those articles, journals, and books from where the
               Wound infection was not seen in any of the patients who   literature for this article has been reviewed and discussed.
            underwent LA. On the other hand, wound infection was seen
            in six patients who had undergone MIA, which was again   orcId
            statistically significant (p <0.027). Our results are in agreement
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            with the results of other studies conducted by Naraintran et al.    Shams Ul Bari   https://orcid.org/0000-0002-5245-5440
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            and Pedersen et al.  This higher rate of wound infection in MIA
            group was because these cases were operated in emergency  references
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            wound infections are more. While all LAs were performed in   Appendicitis. Curr Probl Surg 2005;42(10):688–742. DOI: 10.1067/j.
            main theatre as laparoscope is not available in emergency theatre   cpsurg.2005.07.005.
            of our hospital. Those who developed wound infection were     2.  Majeed AW, Troy G, Nicholl JP, et al. Randomized, prospective,
            managed conservatively with IV antibiotics and daily dressings.   single-blind comparison of laparoscopic versus small-incision
            Two patients with wound infection had wound dehiscence and   cholecystectomy. Lancet 1996;347(9007):989–994. DOI: 10.1016/
            needed secondary suturing.                              s0140-6736(96)90143-9.
               Two patients from MIA group developed intra-abdominal     3.  Hellberg A, Rudberg C, Kullman E, et al. Prospective randomized
                                                                    multicentre study of laparoscopic versus open appendicectomy. Br
            abscess and both patients were managed conservatively with   J Surg 1999;86(1):48–53. DOI: 10.1046/j.1365-2168.1999.00971.x.
            intravenous fluids and intravenous antibiotics and were discharged     4.  Heikkinen TJ, Haukipuro K, Hulkko A. Cost-effective appendectomy.
            after complete recovery without any intervention. On the other   Open or laparoscopic? A prospective randomized study. Surg Endosc
            hand, one patient from LA group reported back to hospital, five   1998;12(10):1204–1208. DOI: 10.1007/s004649900821.
            days after discharge from hospital with sepsis. The patient was     5.  Katkhouda N, Mason RJ, Towfigh S, et al. Laparoscopic versus open
            evaluated with ultrasonography and CT abdomen which revealed   appendectomy: a prospective randomized double-blind study. Ann
            large intra-abdominal abscess. The patient was taken for diagnostic   Surg 2005;242(3):439–448. DOI: 10.1097/01.sla.0000179648.75373.2f.
            laparoscopy and about 1 L of pus was drained; normal saline washes     6.  Ellis H, Nathanson LK. Maingot’s abdominal operations. In: Michael
                                                                    JZ, Stanley WA, Douglas SS, editors. Appendix and Appendectomy,
            were given and drain was placed and finally patient was discharged   11th edition, New York: McGraw-Hill Professional, 2007, pp.589–608.
            after five days. The p-value was statistically insignificant (p = 1). Our      7.  Frazee RC, Roberts JW, Symmonds RE, et al. A prospective randomized
                                                   9
            results were comparable with studies of Chung et al.  and Garbutt   trial comparing open versus laparoscopic appendectomy. Ann Surg
                24
            et al.  In this study, four patients from MIA group developed   1994;219(6):725–728. DOI: 10.1097/00000658-199406000-00017.
            ileus, while none of the patients from LA group developed ileus       8.  Golub R, Siddiqui F, Pohl D. Laparoscopic versus open appendectomy:
            (p = 0.118). Results of this study were in contrast to the results of   A meta-analysis. J Am Coll Surg 1998;186:545–553. DOI: 10.1016/
            the study done by Shaikh et al. 22                      s1072-7515(98)00080-5.
               In this study, 3 patients from MIA group developed intestinal     9.  Chung RS, Rowland DY, Li P. A meta-analysis of randomized controlled
                                                                    trials of laparoscopic versus conventional appendectomy. Am J Surg
            obstruction during a follow-up period of 4 weeks and were   1999;177(3):250–256. DOI: 10.1016/s0002-9610(99)00017-3.
            managed conservatively. Our results were comparable with the     10.  Sauerland S, Lefering R, Holthausen U, et al. Laparoscopic vs
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            results of the study done by Golub et al.  and Biondi et al. 25  conventional appendectomy: A meta-analysis of randomized
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            while 44 patients resumed orals 24 hours after surgery. On the   s004230050135.
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            10 patients resumed orals between 12–24 hours and 3 patients   surgery for suspected appendicitis. Cochrane Database Syst Rev
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            in favor of LA (p <0.001). Our results are in agreement with the results     12.  Deshmukh S, Verde F, Johnson PT, et al. Anatomical variants and
                                                                    pathologies of the vermix. Emerg Radiol 2014;21:543–552. DOI:
            of study conducted by Shaikh et al. 22                  10.1007/s10140-014-1206-4.
               In MIA group, only 2 patients returned to routine work within     13.  Uptal D. Laparoscopic vs open appendectomy. Chin J Dig Dis
            2 weeks, while 50 patients resumed normal work after 2 weeks. In   2005;6:165–169. DOI: 10.1111/j.1443-9573.2005.00225.x.

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