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Hana Alhomoud 10.5005/jp-journals-10033-1266
ORIGINAL ARTICLE

The Effect of Tranexamic Acid on Blood Loss during

Laparoscopic Sleeve Gastrectomy

Hana Alhomoud

ABSTRACT 30 years (Fig. 1). Tranexamic acid has also been used
Background: Tranexamic acid (TXA) is an antifibrinolytic drug in the prophylaxis and treatment of patients at high
that has the property to reduce intraoperative and postoperative risk of intra- and postoperative hemorrhage such as
bleeding. This study was intended to establish the effect of TXA hemophiliacs and patients on thrombolytic therapy and
in minimizing the intraoperative and postoperative blood loss has been found to be highly effective, without significant
in laparoscopic sleeve gastrectomy. side effects. 1-6

Materials and methods: This was a prospective follow-up To reduce intraoperative blood loss and the need for
study conducted in Sabah Hospital, Kuwait, over 4 months blood transfusion, new pharmacologic agents have been
from September 2014 to December 2014. A total of 50 patients developed. The clinical efficacy of these agents has been
who underwent laparoscopic sleeve gastrectomy were included reviewed, and it has been reported that antifibrinolytic
in this study; 25 patients were given tranexamic acid during agents such as aprotinin and TXA are effective in
induction and 25 did not receive. Selection of patients was done
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on a random basis. Intraoperative blood loss, visibility of field reducing packed red blood cell transfusion. The lysine
of surgery, and amount of blood collected in suction apparatus analog inhibitor TXA is particularly effective in reducing
used during surgery. perioperative blood loss in various surgical procedures,
with no reported adverse effects. 8
Results: Each group consisted of 25 patients. Preoperative
intravenous bolus administration of TXA at 10 mg/kg reduces The intravenous and tropical TXA formulations have
blood loss. been reported to be effective in decreasing blood loss in
some studies. 9-11
Conclusion: Tranexamic acid is an antifibrinolytic agent that The aim of this study was to assess the effect of single
inhibits the action of plasmin. There is also reduction in blood
level of D-dimer. It is seen to significantly reduce intraoperative intravenous preoperative dose of TXA on blood loss
blood loss during surgery. Additionally, there seems to be no during laparoscopic sleeve gastrectomy.
alterations of coagulation parameters or untoward systemic
effects. This should prompt further trials. SITE OF ACTION
Keywords: Blood loss, Laparoscopic sleeve gastrectomy,
Tranexamic acid.
How to cite this article: Alhomoud H. The Effect of Tranexamic
Acid on Blood Loss during Laparoscopic Sleeve Gastrectomy.
World J Lap Surg 2016;9(1):30-33.

Source of support: Nil
Conflict of interest: None

INTRODUCTION
Fig. 1: Source: Wikipedia
Tranexamic acid (TXA) is an antifibrinolytic agent and
its predecessor epsilon aminocaproic acid has been used
to treat postoperative bleeding in healthy adults for over MATERIALS AND METHODS
This is a prospective randomized study. The study
period is 4 months from September 2014 to December
Consultant 2014. A total of 50 patients who underwent laparoscopic
Department of Surgery, Al-Sabah Hospital, Kuwait City sleeve gastrectomy were included in the study. The
Kuwait patients were grouped as treatment (case) group and
Corresponding Author: Hana Alhomoud, Consultant control group. The randomization was done by the rules
Department of Surgery, Al-Sabah Hospital, Kuwait City, Kuwait of odd and even. In 25 patients of treatment group, a
Phone: +96599227676, e-mail: hana_alhomoud@hotmail.com
single dose of TXA, 10 mg/kg bodyweight was given
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