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                             LINX Magnetic Esophageal Sphincter Augmentation vs Laparoscopic Nissen Fundoplication for GERD
          the reflux of gastric contents into the esophagus while  and four cases were subjected to a revision surgery due
          maintaining a physiological LES tone, allowing the  to hiatal hernia recurrence. 12,13  The MSA group mor-
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          passage of the food bolus.  Magnetic sphincter augmen-  bidity included one pleural injury, two incidences of
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          tation serves the surgeon and the patient with a faster,  intra operative bleeding, one pneumothorax,  and one gas-
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          simpler, and less invasive tool to effectively treat GERD.  troesophageal obstruction.  Two patients had their device
          On comparison, the LNF is a difficult procedure with  removed, one had treatment failure, and the other patient
          the outcomes based on the skill and experience of the  had dysphagia secondary to device erosion 18 months after
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          surgeon.  It eliminates the need for extensive dissection  the surgery. No mortalities were reported.
          of esophagus and mobilization of gastric fundus, which
          is the hallmark of the LNF procedure. The long-term  CONCLUSION
          complications of MSA reversibility are still unclear, as   Magnetic sphincter augmentation appears to be an
          in cases where the device may be removed using the   effective treatment for GERD, with short-term outcomes
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          minimally invasive technique.  The device is currently   comparable to the more technically challenging and time-
          compatible with 1.5 Tesla magnetic resonance imaging.  consuming LNF. It has a favorable side-effect profile for
             Magnetic sphincter augmentation is not indicated in   the majority of the morbidities associated with GERD
          patients with large paraesophageal hernias, esophageal   surgery. In order to further understand the efficacy of
          dysmotility, and hence considered less versatile than LNF.   MSA, a long-term comparative outcome data past 1 year
          The notable drawback associated with MSA is dysphagia   are needed.
          reported as more severe and lasts longer than LNF-
          associated dysphagia. However, a graduated modified   REFERENCES
          diet and endoscopic balloon dilation have alleviated the
          dysphagia features in patients.                       1.  El-Serag HB, Sweet S, Winchester CC, Dent J. Update on
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                                                                  systematic review. Gut 2014 Jun;63(6):871-880.
          LIMITATION                                            2.  Toghanian S, Johnson DA, Stålhammar NO, Zerbib F. Burden

          This study was basically done with case series and there   of gastro-oesophageal reflux disease in patients with persis-
          were no randomized controlled trials. Moreover, there   tent and intense symptoms despite proton pump inhibitor
                                                                  therapy. Clin Drug Investig 2011 Oct;31(10):703-715.
          were only a few studies comparing MSA and LNF with     3.  Castell DO, Kahrilas PJ, Richter JE, Vakil NB, Johnson DA,
          regard to the outcome on long-term basis.               Zuckerman S, Skammer W, Levine JG. Esomeprazole (40 mg)
                                                                  compared with lansoprazole (30 mg) in the treatment of
          RESULTS                                                 erosive esophagitis. Am J Gastroenterol 2002 Mar;97(3):
                                                                  575-583.
          There were two retrospective case–control studies 11,12  and     4.  Labenz J, Malfertheiner P. Treatment of uncomplicated reflux
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          a prospective control study  taken into consideration for   disease. World J Gastroenterol 2005 Jul;11(28):4291-4299.
          the review. A total of 688 patients were identified, and     5.  Kinoshita Y, Ishihara S. Causes of, and therapeutic approaches
          273 patients had undergone LNF; 415 patients went for   for, proton pump inhibitor-resistant gastroesophageal reflux
          LINX MSA. The mean duration of follow-up was almost     disease in Asia. Ther Adv Gastroenterol 2008 Nov;1(3):
                                                                  191-199.
          the same term ranging from 8 to 18 months for both MSA     6.  Kawamura O, Hosaka H, Shimoyama Y, Kawada A,
          and LNF groups.                                         Kuribayashi S, Kusano M, Yamada M. Evaluation of proton
             Males accounted for 46% of LNF and 57% of MSA.       pump inhibitor-resistant nonerosive reflux disease by
          Mean age was 50 and 58 years for LNF and MSA respec-    esophageal manometry and 24-hour esophageal impedance
          tively. Both groups had similar duration of reflux disease.   and pH monitoring. Digestion 2015 Jan;91(1):19-25.
          Hiatal hernia was present in 70% of the LNF group of     7.  Patti MG. An evidence-based approach to the treatment
          patients and in 68% of MSA group.                       of gastroesophageal reflux disease. JAMA Surg 2016
                                                                  Jan;151(1):73-78.
             Magnetic sphincter augmentation was superior to     8.  Yates RB, Oelschlager BK. Surgical treatment of gastro-
          LNF in preserving the patient’s ability to belch and to   esophageal reflux disease. Surg Clin N Am 2015 Jun;95(3):
          emesis, but there was no significant difference between   527-553.
          MSA and LNF with regard to the postoperative problems,     9.  Bonavina L, DeMeester TR, Ganz RA. LINX TM  reflux
          such as bloating, dysphagia, and also in discontinuing   manage ment system: magnetic sphincter augmentation in
          PPI drug therapy.                                       the treatment of gastroesophageal reflux disease. Expert Rev
             Six patients of the MSA group were in need of endo-  Gastroenterol Hepatol 2012;6:667-674.  ®
          scopic balloon dilation, whereas LNF group required     10.  Bonavina L, Saino G, Lipham JC, DeMeester TR. LINX  reflux
                                                                  management system in chronic gastroesophageal reflux: a
          none. Major morbidity of LNF included intraoperative    novel effective technology for restoring the natural barrier
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          pleural injury,  formation of retropharyngeal abscesses,    to reflux. Ther Adv Gastroenterol 2013 Jul;6(4):261-268.
          World Journal of Laparoscopic Surgery, May-August 2017;10(2):54-56                                55
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